During a micro-ultrasound, high-frequency sound waves are measured using transducers and reconstructed to create images. Micro-ultrasounds are capable of anatomical imaging and monitoring certain physiological processes.
Micro-ultrasound technology uses high frequency sound waves of 15 to 80 MHz and can provide image resolution as low as 30 microns. These high-frequency sound waves are generated by a transducer, serving as an interface on the surface of the subject. The transducer is responsible for both transmission and reception of the high frequency sound waves. An image is generated from the acoustic echoes of these sound waves as they are reflected off internal tissue boundaries, returned to the transducer, and converted into an electrical signal by piezoelectric crystals. The electrical signals are reconstructed into a 2-D grayscale image or 3-D images with volumetric measurements.
Ultrasound is a relatively quick imaging technique that:
Ultrasounds can monitor phenotypic changes in both healthy and disease models over time as well as the effects of novel treatment therapies. The use of Doppler also provides functional information on blood flow dynamics. Injected contrast in the form of microbubbles can be used to highlight vasculature and target certain biomarkers.
Specific applications include:
VisualSonics Vevo 770 Imaging Platform
Resolution: ~50 µm